Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)
Identifieur interne : 001002 ( Main/Exploration ); précédent : 001001; suivant : 001003Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)
Auteurs : Oelisoa M. Andriankaja ; James J. Jiménez ; Francisco J. Mu Oz-Torres ; Cynthia M. Pérez ; José L. Vergara ; Kaumudi JoshipuraSource :
- Journal of clinical periodontology [ 0303-6979 ] ; 2015.
Abstract
The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.
To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.
Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.
24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).
Lipid-lowering agents may reduce both systemic and oral inflammatory responses.
Url:
DOI: 10.1111/jcpe.12461
PubMed: 26407668
PubMed Central: 4808494
Affiliations:
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Jiménez</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. 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Andriankaja</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.</p><sec id="S1"><title>Objective</title><p id="P2">To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.</p></sec><sec id="S2"><title>Design</title><p id="P3">Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.</p></sec><sec id="S3"><title>Results</title><p id="P4">24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Lipid-lowering agents may reduce both systemic and oral inflammatory responses.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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